Frankenstein, the monster imagined by an adolescent Mary Shelley in her novel published two hundred years ago, continues to fascinate in an age when the consequences of scientific research and intervention appear increasingly out of control. Fiona Sampson's biography, In Search of Mary Shelley, tracks down the precocious girl and unconventional woman behind the monster. Kathryn Harkup's Making the Monster explores the gruesome scientific background behind Shelley's creation and the gothic novel's influence on cutting edge research. A chemist and author of A is for Arsenic, she knows whereof she speaks. Fiona Sampson is an award-winning poet, editor and translator. They discuss Shelley's monster with cultural historian Christopher Frayling, author of Frankenstein's First Two Hundred Years.